I've been working with AdSpyglass for two months, here are my results:
After I added new advertisers + put the recommended settings, I felt a significant effect. Profit increased up to 50%. Maybe if I had worked with more ads I would have been able to get more results, but I do not have so much traffic and it does not make sense to divide traffic between many ad nets.
The system is worth using. What's more, one free trial month is enough to test the entire inventory and make custom adjustments.